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Moreover, the number of senescent cells also increase with culture time, resulting in a loss of division capabilities, resistance to apoptosis, and the acquisition of a robust proinflammatory secretome known as the senescence-associated secretory phenotype (SASP) (Jeon et al., 2018)

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Specific gut inflammation (190) and gut hyper-permeability (219) have been identified, and microbe and virus communities may also persist in ME/CFS blood and brain tissue (193)