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Low dose NAC was chosen in this study because of its safe side effect profile, however, it is possible that these lower doses prevented therapeutic levels of NAC thereby limiting the beneficial effects

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These findings imply that emodin protects hepatocytes from APAP-induced liver damage by activating Nrf2-mediated antioxidant stress pathways, inhibiting the NLRP3 inflammasome, and downregulating the cGAS-STING signaling pathway (Shen et al., 2022)