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The catabolism pathway of toxic substances participated by glutathione.... | Download Scientific Diagram

7 Conclusion ccRCC takes VHL/HIF inactivation as the molecular basis, forming a metabolic network characterised by enhanced sugar metabolism, lipid droplet/lipid remodelling, reprogramming of amino acid and one-carbon metabolism, and redox imbalance, and mutual traction with the immunosuppressive microenvironment, becoming a key driver of disease progression and treatment tolerance

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