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Yue-Yu Gu, [email protected] † These authors have contributed equally to this work This article was submitted to Renal Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The DNA–PK complex also serves as a key regulator of hyperglycemia-induced endothelial ferroptosis in T2DM cardiomyopathy, potentially representing a novel therapeutic strategy to alleviate T2DM microvascular dysfunction and cardiac dysfunction [97]