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Effect of the synthetic pineal peptide Epithalon on spontaneous carcinogenesis in female C3H/He mice

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The AP1 (activator protein-1) transcription factor family, and the promoter regulatory element ARE, are involved in the regulation of redox homeostasis that can affect the NF-κB, MAPK/ERK/PI3K, and Nrf2 pathways (Figure 2) and modulate gene expression, including certain proteins that control cell cycle progression due to the reduction of PKC (protein kinase C), leading to decreased activation of MAPK/ERK (targeting cyclin D/E1, p27/53) and inflammatory response via inhibition of COX2, and they also regulate angiogenesis through the modulation of VEGF [73]